Article
Competition for nutritional resources masks the true frequency of bacterial mutants.
BMC biology - 14 Dec 2020
Neves Henrique Iglesias, Machado Gabriella Trombini, Ramos Taíssa Cristina Dos Santos, Yang Hyun Mo, Yagil Ezra, Spira Beny
Abstract excerpt
BACKGROUND: It is widely assumed that all mutant microorganisms present in a culture are able to grow and form colonies, provided that they express the features required for selection. Unlike wild-type Escherichia coli, PHO-constitutive mutants overexpress alkaline phosphatase and hence can hydrolyze glycerol-2-phosphate (G2P) to glycerol and form colonies on plates having G2P as the sole carbon source. These...
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