Article
USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans.
Nature neuroscience - 1 Jan 2021
Schwaller Fred, Bégay Valérie, García-García Gema, Taberner Francisco J, Moshourab Rabih, McDonald Brennan, Docter Trevor, Kühnemund Johannes, Ojeda-Alonso Julia, Paricio-Montesinos Ricardo, Lechner Stefan G, Poulet James F A, Millan Jose M, Lewin Gary R
Abstract excerpt
Fingertip mechanoreceptors comprise sensory neuron endings together with specialized skin cells that form the end-organ. Exquisitely sensitive, vibration-sensing neurons are associated with Meissner's corpuscles in the skin. In the present study, we found that USH2A, a transmembrane protein with a very large extracellular domain, was found in terminal Schwann cells within Meissner's corpuscles. Pathogenic USH2A...
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