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Article

Brain Network Simulations Indicate Effects of Neuregulin-1 Genotype on Excitation-Inhibition Balance in Cortical Dynamics.

Cerebral cortex (New York, N.Y. : 1991) - 5 Mar 2021

Klein Pedro Costa, Ettinger Ulrich, Schirner Michael, Ritter Petra, Rujescu Dan, Falkai Peter, Koutsouleris Nikolaos, Kambeitz-Ilankovic Lana, Kambeitz Joseph

Abstract excerpt

Neuregulin-1 (NRG1) represents an important factor for multiple processes including neurodevelopment, brain functioning or cognitive functions. Evidence from animal research suggests an effect of NRG1 on the excitation-inhibition (E/I) balance in cortical circuits. However, direct evidence for the importance of NRG1 in E/I balance in humans is still lacking. In this work, we demonstrate the application of...

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PMID: 33279967
DOI: 10.1093/cercor/bhaa339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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