Article
Beyond the pan-genome: current perspectives on the functional and practical outcomes of the distributed genome hypothesis.
Biochemical Society transactions - 18 Dec 2020
Hammond Jocelyn A, Gordon Emma A, Socarras Kayla M, Chang Mell Joshua, Ehrlich Garth D
Abstract excerpt
The principle of monoclonality with regard to bacterial infections was considered immutable prior to 30 years ago. This view, espoused by Koch for acute infections, has proven inadequate regarding chronic infections as persistence requires multiple forms of heterogeneity among the bacterial population. This understanding of bacterial plurality emerged from a synthesis of what-were-then novel technologies in...
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