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Article

Generation of a human induced pluripotent stem cell line (CPGHi001-A) from a hearing loss patient with the TMC1 p.M418K mutation.

Stem cell research - 1 Dec 2020

Wang Hongyang, Wu Kaiwen, Guan Jing, Wang Qiuju

Abstract excerpt

By using a nonintegrating plasmid delivery system, we generated induced pluripotent stem cells (iPSCs) from the urine cells of a male patient from the family carrying the TMC1 p.M418K mutation. This mutation is homologous to that in Beethoven mice, which were treated by gene editing successfully. The resulting iPSCs had a normal karyotype, showed pluripotency by immunofluorescence staining, and differentiated...

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PMID: 33217648
DOI: 10.1016/j.scr.2020.101982

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