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Article

Clinical Characteristics of Short-Stature Patients With an NPR2 Mutation and the Therapeutic Response to rhGH.

The Journal of clinical endocrinology and metabolism - 23 Jan 2021

Ke Xiaoan, Liang Hanting, Miao Hui, Yang Hongbo, Wang Linjie, Gong Fengying, Pan Hui, Zhu Huijuan

Abstract excerpt

CONTEXT: The natriuretic peptide receptor 2 gene (NPR2) is a causative gene of idiopathic short stature (ISS) with an incidence rate of 2% to 6%. The clinical characteristics of patients with NPR2 heterozygous mutations are atypical, and data on the efficacy of recombinant human growth hormone (rhGH) treatment in patients with NPR2 mutations are limited. OBJECTIVES: This work reports 6 cases with NPR2 mutation...

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PMID: 33205215
DOI: 10.1210/clinem/dgaa842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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