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Article

Al-Tolerant Barley Mutant hvatr.g Shows the ATR-Regulated DNA Damage Response to Maleic Acid Hydrazide.

International journal of molecular sciences - 12 Nov 2020

Jaskowiak Joanna, Kwasniewska Jolanta, Szurman-Zubrzycka Miriam, Rojek-Jelonek Magdalena, Larsen Paul B, Szarejko Iwona

Abstract excerpt

ATR, a DNA damage signaling kinase, is required for cell cycle checkpoint regulation and detecting DNA damage caused by genotoxic factors including Al3+ ions. We analyzed the function of the HvATR gene in response to chemical clastogen-maleic acid hydrazide (MH). For this purpose, the Al-tolerant barley TILLING mutant hvatr.g was used. We described the effects of MH on the nuclear genome of hvatr.g mutant and its...

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PMID: 33198069
DOI: 10.3390/ijms21228500
PMCID: PMC7697149

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