Article
Molecular Docking and QSAR Studies as Computational Tools Exploring the Rescue Ability of F508del CFTR Correctors.
International journal of molecular sciences - 29 Oct 2020
Righetti Giada, Casale Monica, Liessi Nara, Tasso Bruno, Salis Annalisa, Tonelli Michele, Millo Enrico, Pedemonte Nicoletta, Fossa Paola, Cichero Elena
Abstract excerpt
Cystic fibrosis (CF) is the autosomal recessive disorder most recurrent in Caucasian populations. Different mutations involving the cystic fibrosis transmembrane regulator protein (CFTR) gene, which encodes the CFTR channel, are involved in CF. A number of life-prolonging therapies have been conceived and deeply investigated to combat this disease. Among them, the administration of the so-called CFTR modulators,...
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