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DDX56 Binds to Chikungunya Virus RNA To Control Infection

26 Oct 2020

Abstract excerpt

Arthropod-borne viruses are diverse pathogens and include the emerging virus chikungunya virus, which is associated with human disease. Through genetic screening, we found that the conserved RNA binding protein DDX56 is antiviral against chikungunya virus in insects and humans. DDX56 relocalizes from the nucleus to the cytoplasm, where it binds to a stem-loop in the viral genome and destabilizes incoming genomes....

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PMID: 33109765
DOI: 10.1128/mbio.02623-20

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