Article
Genome-wide methylation analysis in Silver-Russell syndrome, Temple syndrome, and Prader-Willi syndrome.
Clinical epigenetics - 22 Oct 2020
Hara-Isono Kaori, Matsubara Keiko, Fuke Tomoko, Yamazawa Kazuki, Satou Kazuhito, Murakami Nobuyuki, Saitoh Shinji, Nakabayashi Kazuhiko, Hata Kenichiro, Ogata Tsutomu, Fukami Maki, Kagami Masayo
Abstract excerpt
BACKGROUND: Imprinting disorders (IDs) show overlapping phenotypes, particularly in Silver-Russell syndrome (SRS), Temple syndrome (TS14), and Prader-Willi syndrome (PWS). These three IDs include fetal and postnatal growth failure, feeding difficulty, and muscular hypotonia as major clinical features. However, the mechanism that causes overlapping phenotypes has not been clarified. To investigate the presence or...
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