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Article

A Three-Generation Pedigree of Multifocal Heterotopic Ossification With Bilateral Involvement.

Orthopedics - 1 Jan 2021

Liu Yang, Zhao Xiao-Dan

Abstract excerpt

Heterotopic ossification (HO) can be classified as nonhereditary HO (NHHO) or hereditary HO (HHO). Hereditary HO includes 2 different forms: fibrodysplasia ossificans progressiva (FOP) and progressive osseous heteroplasia (POH). Each of these disorders is caused by mutations in a single (different) gene. Clinical diagnosis of FOP can be confirmed by sequence analysis of the ACVR1 gene. Fewer than 10 families with...

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PMID: 33089331
DOI: 10.3928/01477447-20201007-01

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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