Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.

doi:10.1126/science.abd2985

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Article

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity.

Science (New York, N.Y.) - 13 Nov 2020

Cantuti-Castelvetri Ludovico, Ojha Ravi, Pedro Liliana D, Djannatian Minou, Franz Jonas, Kuivanen Suvi, van der Meer Franziska, Kallio Katri, Kaya Tuğberk, Anastasina Maria, Smura Teemu, Levanov Lev, Szirovicza Leonora, Tobi Allan, Kallio-Kokko Hannimari, Österlund Pamela, Joensuu Merja, Meunier Frédéric A, Butcher Sarah J, Winkler Martin Sebastian, Mollenhauer Brit, Helenius Ari, Gokce Ozgun, Teesalu Tambet, Hepojoki Jussi, Vapalahti Olli, Stadelmann Christine, Balistreri Giuseppe, Simons Mikael

Abstract excerpt

The causative agent of coronavirus disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the surface of host cells. In this study, we found that neuropilin-1 (NRP1), known to bind furin-cleaved substrates, significantly potentiates SARS-CoV-2 infectivity, an effect...

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PMID: 33082293
DOI: 10.1126/science.abd2985
PMCID: PMC7857391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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