Article
High frequency of clonal hematopoiesis in Erdheim-Chester disease.
Blood - 28 Jan 2021
Cohen Aubart Fleur, Roos-Weil Damien, Armand Marine, Marceau-Renaut Alice, Emile Jean-François, Duployez Nicolas, Charlotte Frédéric, Poulain Stéphanie, Lhote Raphael, Hélias-Rodzewicz Zofia, Della-Valle Véronique, Bernard Olivier, Maloum Karim, Nguyen-Khac Florence, Donadieu Jean, Amoura Zahir, Abdel-Wahab Omar, Haroche Julien
Abstract excerpt
Erdheim-Chester disease (ECD) is a clonal hematopoietic disorder characterized by the accumulation of foamy histiocytes within organs (in particular, frequent retroperitoneal involvement) and a high frequency of BRAFV600E mutations. Although ECD is not commonly recognized to have overt peripheral blood (PB) or bone marrow (BM) disease, we recently identified that ECD patients have a high frequency of a...
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