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Article

Recent advances in therapeutic strategies of Erdheim-Chester disease.

Naunyn-Schmiedeberg's archives of pharmacology - 1 Jun 2025

Doke Rohit, Lokhande Rahul, Chande Kalyani, Vinchurkar Kuldeep, Prajapati Bhupendra G

Abstract excerpt

Erdheim-Chester disease (ECD) is a rare form of non-LCH characterized by excessive accumulation of histiocytes in various tissues, leading to significant morbidity. The estimated prevalence of ECD is low, with fewer than 1000 cases reported globally, yet it presents considerable clinical challenges due to its heterogeneous manifestations, which include bone pain, cardiovascular complications, and neurological...

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Identifiers

PMID: 39836251
DOI: 10.1007/s00210-024-03769-2

Genes

ECD
BRAF

Variants

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