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Article

Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts.

Nucleic acids research - 4 Nov 2020

Xiao Yun, Wang Meng, He Qiufen, Xu Lei, Zhang Qinghai, Meng Feilong, Jia Zidong, Zhang Fengguo, Wang Haibo, Guan Min-Xin

Abstract excerpt

In this report, we investigated the molecular mechanism underlying a deafness-associated m.7516delA mutation affecting the 5' end processing sites of mitochondrial tRNAAsp and tRNASer(UCN). An in vitro processing experiment demonstrated that m.7516delA mutation caused the aberrant 5' end processing of tRNASer(UCN) and tRNAAsp precursors, catalyzed by RNase P. Using cytoplasmic hybrids (cybrids) derived from one...

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Identifiers

PMID: 33045734
DOI: 10.1093/nar/gkaa860
PMCID: PMC7641755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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