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The Meaning of Informed Consent: Genome Editing Clinical Trials for Sickle Cell Disease

1 Oct 2020

Abstract excerpt

Background A first therapeutic target of somatic genome editing (SGE) is sickle cell disease (SCD), the most commonly inherited blood disorders, affecting more than 100,000 individuals in the United States. Advancement of SGE is contingent on patient participation in first in human clinical trials. However, seriously ill patients may be vulnerable to overestimating the benefits of early phase studies while...

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PMID: 33044907
DOI: 10.1080/23294515.2020.1818876

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