Myogenic, genomic and non‐genomic influences of the vitamin D axis in skeletal muscle

Abstract excerpt

Despite vitamin D‐deficiency clinically presenting with myopathy, muscle weakness and atrophy, the mechanisms by which vitamin D exerts its homeostatic effects upon skeletal muscle remain to be fully established. Recent studies have shown that the receptor by which 1α,25‐dihydroxyvitamin D 3 (1,25[OH] 2 D 3 ) exerts its biological actions (ie, the vitamin D receptor, VDR) elicits both genomic and non‐genomic...

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