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Article

Dnmt3b regulates DUX4 expression in a tissue-dependent manner in transgenic D4Z4 mice.

Skeletal muscle - 1 Oct 2020

Bouwman Linde F, den Hamer Bianca, Verveer Elwin P, Lerink Lente J S, Krom Yvonne D, van der Maarel Silvère M, de Greef Jessica C

Abstract excerpt

BACKGROUND: Facioscapulohumeral muscular dystrophy (FSHD) is a skeletal muscle disorder that is caused by derepression of the transcription factor DUX4 in skeletal muscle cells. Apart from SMCHD1, DNMT3B was recently identified as a disease gene and disease modifier in FSHD. However, the exact role of DNMT3B at the D4Z4 repeat array remains unknown. METHODS: To determine the role of Dnmt3b on DUX4 repression,...

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Identifiers

PMID: 33004076
DOI: 10.1186/s13395-020-00247-0
PMCID: PMC7528343

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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