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Article

Prefrontal Cortex Transcriptomic Deconvolution Implicates Monocyte Infiltration in Parkinson’s Disease

1 Jan 2020

Abstract excerpt

INTRODUCTION: Although not considered a primary cause, neuroinflammation is associated with many neurodegenerative disorders, including Parkinson's disease (PD). METHODS: To elucidate potential immune involvement in PD, the present study imputed immune cell abundances from bulk RNA-sequencing transcriptomic data of PD postmortem prefrontal cortices. CIBERSORTx, an RNA deconvolution algorithm that implements...

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PMID: 32980850
DOI: 10.1159/000510218

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