Article
The Genetic Diversification of a Single Bluetongue Virus Strain Using an In Vitro Model of Alternating-Host Transmission.
Viruses - 18 Sept 2020
Kopanke Jennifer H, Lee Justin S, Stenglein Mark D, Mayo Christie E
Abstract excerpt
Bluetongue virus (BTV) is an arbovirus that has been associated with dramatic epizootics in both wild and domestic ruminants in recent decades. As a segmented, double-stranded RNA virus, BTV can evolve via several mechanisms due to its genomic structure. However, the effect of BTV's alternating-host transmission cycle on the virus's genetic diversification remains poorly understood. Whole genome sequencing...
Topics
- Animals
- Bluetongue
- Bluetongue virus
- Cattle
- Ceratopogonidae
- Endothelial Cells
- Genetic Variation
- Peptide Hydrolases
- Serial Passage
- Viral Proteins
- Virus Replication
