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Modulation of acyl-carnitines, the broad mechanism behind Wolbachia -mediated inhibition of medically important flaviviruses in Aedes aegypti

10 Sept 2020

Abstract excerpt

Significance Wolbachia ( w Mel strain)-infected Aedes aegypti mosquitoes are refractory to disseminated arboviral infections. Yet previous studies into the mechanism behind Wolbachia -mediated virus blocking have not considered the involvement of lipids, apart from cholesterol, during superinfection. We used liquid chromatography mass spectrometry to study the lipidome in mosquito cells infected with virus, w...

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PMID: 32913052
DOI: 10.1073/pnas.1914814117

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