Article
The Impact of Insertion Sequences on O-Serotype Phenotype and Its O-Locus-Based Prediction in Klebsiella pneumoniae O2 and O1.
International journal of molecular sciences - 8 Sept 2020
Artyszuk Daria, Izdebski Radosław, Maciejewska Anna, Kaszowska Marta, Herud Aleksandra, Szijártó Valeria, Gniadkowski Marek, Lukasiewicz Jolanta
Abstract excerpt
Klebsiella pneumoniae is a nosocomial pathogen, pointed out by the World Helth Organisation (WHO) as "critical" regarding the highly limited options of treatment. Lipopolysaccharide (LPS, O-antigen) and capsular polysaccharide (K-antigen) are its virulence factors and surface antigens, determining O- and K-serotypes and encoded by O- or K-loci. They are promising targets for antibody-based therapies (vaccines and...
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