Article
The Role of MicroRNAs in Arrhythmogenic Cardiomyopathy: Biomarkers or Innocent Bystanders of Disease Progression?
International journal of molecular sciences - 3 Sept 2020
Bueno Marinas Maria, Celeghin Rudy, Cason Marco, Thiene Gaetano, Basso Cristina, Pilichou Kalliopi
Abstract excerpt
Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease characterized by a progressive fibro-fatty replacement of the working myocardium and by life-threatening arrhythmias and risk of sudden cardiac death. Pathogenic variants are identified in nearly 50% of affected patients mostly in genes encoding for desmosomal proteins. AC incomplete penetrance and phenotypic variability advocate that other...
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