Article
A LINE-1 insertion situated in the promoter of IMPG2 is associated with autosomal recessive progressive retinal atrophy in Lhasa Apso dogs.
BMC genetics - 7 Sept 2020
Hitti-Malin Rebekkah J, Burmeister Louise M, Ricketts Sally L, Lewis Thomas W, Pettitt Louise, Boursnell Mike, Schofield Ellen C, Sargan David, Mellersh Cathryn S
Abstract excerpt
BACKGROUND: Canine progressive retinal atrophies are a group of hereditary retinal degenerations in dogs characterised by depletion of photoreceptor cells in the retina, which ultimately leads to blindness. PRA in the Lhasa Apso (LA) dog has not previously been clinically characterised or described in the literature, but owners in the UK are advised to have their dog examined through the British Veterinary...
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