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Article

An intronic LINE-1 insertion in MERTK is strongly associated with retinopathy in Swedish Vallhund dogs.

PloS one - 1 Jan 2017

Everson Richard, Pettitt Louise, Forman Oliver P, Dower-Tylee Olivia, McLaughlin Bryan, Ahonen Saija, Kaukonen Maria, Komáromy András M, Lohi Hannes, Mellersh Cathryn S, Sansom Jane, Ricketts Sally L

Abstract excerpt

The domestic dog segregates a significant number of inherited progressive retinal diseases, several of which mirror human retinal diseases and which are collectively termed progressive retinal atrophy (PRA). In 2014, a novel form of PRA was reported in the Swedish Vallhund breed, and the disease was mapped to canine chromosome 17. The causal mutation was not identified, but expression analyses of the retinas of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28813472
DOI: 10.1371/journal.pone.0183021
PMCID: PMC5558984

Genes

MERTK

Provenance

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An intronic LINE-1 insertion in MERTK is strongly associated with retinopathy in Swedish Vallhund dogs.PMID 28813472Read ↗

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