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C-Type Lectins Link Immunological and Reproductive Processes in Aedes aegypti

21 Aug 2020

Abstract excerpt

mutants showed significantly reduced DENV-2 infection rate and gut commensal microbiota populations, as well as upregulated JAK/STAT, IMD, Toll, and AMPs immunological pathways. Mutants also had significantly shorter lifespans than controls and laid fewer eggs due to defective germ line development. dsRNA knock-down of Attacin and Gambicin, two targets of the AMPs pathway, partially rescued this reduction in...

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PMID: 32891883
DOI: 10.1016/j.isci.2020.101486

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