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Kinship analysis on single cells after whole genome amplification.

Scientific reports - 4 Sept 2020

Weymaere Jana, Vander Plaetsen Ann-Sophie, Tilleman Laurentijn, Tytgat Olivier, Rubben Kaat, Geeraert Sofie, Deforce Dieter, Van Nieuwerburgh Filip

Abstract excerpt

Short Tandem Repeat (STR-) and Single Nucleotide Polymorphism (SNP-) genotyping have been extensively studied within forensic kinship analysis. Nevertheless, no results have been reported on kinship analysis after whole genome amplification (WGA) of single cells. This WGA step is a necessary procedure in several applications, such as cell-based non-invasive prenatal testing (cbNIPT) and pre-implantation genetic...

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PMID: 32887915
DOI: 10.1038/s41598-020-71562-1
PMCID: PMC7474072

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