Article
Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits.
Communications biology - 28 Aug 2020
Wang Yuzhe, Cao Xuemin, Luo Chenglong, Sheng Zheya, Zhang Chunyuan, Bian Cheng, Feng Chungang, Li Jinxiu, Gao Fei, Zhao Yiqiang, Jiang Ziqin, Qu Hao, Shu Dingming, Carlborg Örjan, Hu Xiaoxiang, Li Ning
Abstract excerpt
In depth studies of quantitative trait loci (QTL) can provide insights to the genetic architectures of complex traits. A major effect QTL at the distal end of chicken chromosome 1 has been associated with growth traits in multiple populations. This locus was fine-mapped in a fifteen-generation chicken advanced intercross population including 1119 birds and explored in further detail using 222 sequenced genomes...
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