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A Linear Regression and Deep Learning Approach for Detecting Reliable Genetic Alterations in Cancer Using DNA Methylation and Gene Expression Data.

Genes - 12 Aug 2020

Mallik Saurav, Seth Soumita, Bhadra Tapas, Zhao Zhongming

Abstract excerpt

DNA methylation change has been useful for cancer biomarker discovery, classification, and potential treatment development. So far, existing methods use either differentially methylated CpG sites or combined CpG sites, namely differentially methylated regions, that can be mapped to genes. However, such methylation signal mapping has limitations. To address these limitations, in this study, we introduced a...

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PMID: 32806782
DOI: 10.3390/genes11080931
PMCID: PMC7465138

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