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Article

Apatinib induces apoptosis and autophagy via the PI3K/AKT/mTOR and MAPK/ERK signaling pathways in neuroblastoma

27 Jul 2020

Abstract excerpt

The clinical outcome of neuroblastoma (NB) has significantly improved in the last 30 years for patients with localized disease; however, the overall survival (OS) for patients with metastasis remains poor. Apatinib, a selective inhibitor of the vascular endothelial growth factor receptor‑2 (VEGFR‑2) tyrosine kinase, which was discovered to be highly associated with metastasis, has been reported to exert antitumor...

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Identifiers

PMID: 32788939
DOI: 10.3892/ol.2020.11913

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