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Polymorphisms associated to bovine paratuberculosis: investigation of their role in DNA-protein interactions and transcriptional regulation.

Veterinaria italiana - 31 Dec 2020

Aryngaziyev Berik, Beltramo Chiara, Dondo Alessandro, Karymsakov Talgat, Varello Katia, Goria Maria, Di Blasio Alessia, Nodari Sabrina, Colussi Silvia, Modesto Paola, Daugaliyeva Aida, Acutis Pier Luigi, Daugaliyeva Saule, Peletto Simone

Abstract excerpt

Previous studies led to identify SNPs in putative regulatory regions of the SLC11A1 and CARD15 genes with association to paratuberculosis in cattle. Aim of this study was to investigate the role of these mutations at the regulatory level by DNA-protein interaction analyses and transcriptome comparison between wild-type and mutated animals. Gene regions carrying the SNPs of interest were analysed by bioinformatic...

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PMID: 32761582
DOI: 10.12834/VetIt.2325.13205.1

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