Article
VPS4B mutation impairs the osteogenic differentiation of dental follicle cells derived from a patient with dentin dysplasia type I.
International journal of oral science - 31 Jul 2020
Li Qiang, Lu Fangli, Chen Tianxuan, Zhang Ke, Lu Yuping, Li Xiaocong, Wang Yingying, Liu Ling, Tian Qing, Xiong Fu, Chen Dong
Abstract excerpt
A splicing mutation in VPS4B can cause dentin dysplasia type I (DD-I), a hereditary autosomal-dominant disorder characterized by rootless teeth, the etiology of which is genetically heterogeneous. In our study, dental follicle cells (DFCs) were isolated and cultured from a patient with DD-I and compared with those from an age-matched, healthy control. In a previous study, this DD-I patient was confirmed to have a...
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