Article
The molecular effect of a polymorphic microRNA binding site of Wolfram syndrome 1 gene in dogs.
BMC genetics - 28 Jul 2020
Koller Dora, Kubinyi Eniko, Elek Zsuzsanna, Nemeth Helga, Miklosi Adam, Sasvari-Szekely Maria, Ronai Zsolt
Abstract excerpt
BACKGROUND: Although the molecular function of wolframin remains unclear, the lack of this protein is known to cause stress in the endoplasmic reticulum. Some variants in the Wolfram Syndrome 1 gene (WFS1) were associated with various neuropsychiatric disorders in humans, such as aggressiveness, impulsivity and anxiety. RESULTS: Here we present an in silico study predicting a single nucleotide polymorphism...
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