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Article

Identification of SORCS1 as a candidate gene associated with canine behavioral traits: Insights from guide dog training outcomes.

PloS one - 1 Jan 2026

Omi Toshinori, Udagawa Chihiro, Kato Yuiko, Kawakami Shota, Uno Yumiko, Ochiai Kazuhiko, Asano Junzo

Abstract excerpt

Although genetic factors contribute to behavioral variation in working dogs, the underlying molecular determinants remain poorly understood. The sortilin-related VPS10 domain-containing receptor 1 (SORCS1) gene is highly expressed in the central nervous system and has been implicated in neuronal signaling and synaptic regulation. A preliminary genome-wide association study suggested an association between SORCS1...

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Identifiers

PMID: 41701742
DOI: 10.1371/journal.pone.0342346
PMCID: PMC12912605

Genes

SORCS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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