Article
Differential evolution and neofunctionalization of snake venom metalloprotease domains.
Molecular & cellular proteomics : MCP - 1 Mar 2013
Brust Andreas, Sunagar Kartik, Undheim Eivind A B, Vetter Irina, Yang Daryl C, Yang Dary C, Casewell Nicholas R, Jackson Timothy N W, Koludarov Ivan, Alewood Paul F, Hodgson Wayne C, Lewis Richard J, King Glenn F, Antunes Agostinho, Hendrikx Iwan, Fry Bryan G
Abstract excerpt
Snake venom metalloproteases (SVMP) are composed of five domains: signal peptide, propeptide, metalloprotease, disintegrin, and cysteine-rich. Secreted toxins are typically combinatorial variations of the latter three domains. The SVMP-encoding genes of Psammophis mossambicus venom are unique in containing only the signal and propeptide domains. We show that the Psammophis SVMP propeptide evolves rapidly and is...
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