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Analysis of tumor mutational burden: correlation of five large gene panels with whole exome sequencing

9 Jul 2020

Abstract excerpt

Outcome of immune checkpoint inhibition in cancer can be predicted by measuring PDL1 expression of tumor cells. Search for additional biomarkers led to tumor mutational burden (TMB) as surrogate marker for neoantigens presented. While TMB was previously determined via whole exome sequencing (WES), there have been approaches with comprehensive gene panels as well. We sequenced samples derived from formalin-fixed...

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PMID: 32647293
DOI: 10.1038/s41598-020-68394-4

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