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Article

Neoepitopes as Difference Makers for General Cancer Vaccines?

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2020

Filderman Jessica N, Storkus Walter J

Abstract excerpt

The cancer mutanome has been associated with disease prognosis as well as response to interventional immunotherapy and provides a substrate for development of personalized vaccines targeting tumor neoepitopes. Recent findings suggest that neoantigen-based vaccines may represent general interventional approaches for patients with solid cancers, regardless of their inherent mutational burden.See related article by...

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Identifiers

PMID: 32646923
DOI: 10.1158/1078-0432.CCR-20-2127
PMCID: PMC7484287

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