Article
Genetic defects of autophagy linked to disease.
Progress in molecular biology and translational science - 1 Jan 2020
Fraiberg Milana, Elazar Zvulun
Abstract excerpt
Autophagy is a highly conserved lysosomal degradation pathway responsible for rapid elimination of unwanted cytoplasmic materials in response to stressful conditions. This cytoprotective function is essential for maintenance of cellular homeostasis and is mediated by conserved autophagy-related genes (ATG) and autophagic receptors. Impairment of autophagy frequently results in a wide variety of human pathologies....
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