Article
A contemporary perspective on the diagnosis and treatment of diffuse gliomas in adults.
Swiss medical weekly - 1 Jun 2020
Roth Patrick, Hottinger Andreas F, Hundsberger Thomas, Läubli Heinz, Schucht Philippe, Reinert Michael, Mamot Christoph, Roelcke Ulrich, Pesce Gianfranco, Hofer Silvia, Weller Michael
Abstract excerpt
Gliomas are intrinsic brain tumours, which are classified by the World Health Organization (WHO) into different grades of malignancy, with glioblastoma being the most frequent and most malignant subtype (WHO grade IV). Mutations in the isocitrate dehydrogenase (IDH) 1 or 2 genes are frequent in lower (WHO II/III) grade tumours but typically absent in classical glioblastoma. IDH mutations are associated with a...
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