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Article

Ancestral contribution of the muscle-specific creatine kinase (CKM) polymorphism rs4884 in the knee osteoarthritis risk: a preliminary study.

Clinical rheumatology - 1 Jan 2021

Fernández-Torres Javier, Martínez-Nava Gabriela Angélica, Zamudio-Cuevas Yessica, Barbier Olivier Christophe, Narváez-Morales Juana, Martínez-Flores Karina

Abstract excerpt

INTRODUCTION/OBJECTIVES: Articular cartilage and periarticular muscle tissues are strongly affected during knee osteoarthritis (OA). Creatine kinase (CK) is an enzyme expressed in several tissues, but the isoform CK-MM is specific of skeletal muscle, and its serum concentration is used as a biomarker of muscle damage. Genetic variants of the CKM gene have been associated with various pathologies, but to date,...

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PMID: 32557253
DOI: 10.1007/s10067-020-05238-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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