Article
Ganab Haploinsufficiency Does Not Cause Polycystic Kidney Disease or Polycystic Liver Disease in Mice.
BioMed research international - 1 Jan 2020
Geng Guangrui, Xiao Yunming, Zhang Yingjie, Shen Wanjun, Liu Jiaona, Zhu Fei, Wang Xu, Wu Jie, Liu Ran, Cai Guangyan, Bai Xueyuan, Li Qinggang, Chen Xiangmei
Abstract excerpt
BACKGROUND: Heterozygous GANAB mutations that can cause autosomal dominant polycystic kidney disease (ADPKD) and polycystic liver disease (PLD) have been described previously, but their roles in ADPKD and PLD are largely unknown. With the increase in polycystic kidney disease caused by GANAB gene mutations in recent years, a suitable animal model is still needed to further explore the pathogenic role of this...
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