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Germline Genetic Mutations in a Multi-center Contemporary Cohort of 550 Phyllodes Tumors: An Opportunity for Expanded Multi-gene Panel Testing.

Annals of surgical oncology - 1 Oct 2020

Rosenberger Laura H, Thomas Samantha M, Nimbkar Suniti N, Hieken Tina J, Ludwig Kandice K, Jacobs Lisa K, Miller Megan E, Gallagher Kristalyn K, Wong Jasmine, Neuman Heather B, Tseng Jennifer, Hassinger Taryn E, Jakub James W

Abstract excerpt

BACKGROUND: A paucity of data exists regarding inherited mutations associated with phyllodes tumors (PT); however, some are reported (TP53, BRCA1, and RB1). A PT diagnosis does not meet NCCN criteria for testing, including within Li-Fraumeni Syndrome (TP53). We sought to determine the prevalence of mutations associated with PT. METHODS: We performed an 11-institution review of contemporary (2007-2017) PT...

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Identifiers

PMID: 32504368
DOI: 10.1245/s10434-020-08480-z
PMCID: PMC9945652

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