An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons.

doi:10.1371/journal.pgen.1008822

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Article

An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene conversion and transposons.

PLoS genetics - 1 Jun 2020

Weedall Gareth D, Riveron Jacob M, Hearn Jack, Irving Helen, Kamdem Colince, Fouet Caroline, White Bradley J, Wondji Charles S

Abstract excerpt

Insecticide resistance in malaria vectors threatens to reverse recent gains in malaria control. Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to improving control strategies and preventing malaria resurgence. A genome-wide survey of Anopheles funestus genetic diversity Africa-wide revealed evidences of a major division between southern Africa and elsewhere, associated...

Topics

Africa
Alleles
Animals
Anopheles
Cytochrome P450 Family 6
DNA Copy Number Variations
DNA Transposable Elements
Evolution, Molecular
Gene Flow
Genetic Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Insect

Haplotypes

Humans

Insect Proteins

Insecticide Resistance

Malaria

Metagenomics

Mosquito Control

Source

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Identifiers

PMID: 32497040
DOI: 10.1371/journal.pgen.1008822
PMCID: PMC7297382

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