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Article

Functional specification of CCK+ interneurons by alternative isoforms of Kv4.3 auxiliary subunits.

eLife - 3 Jun 2020

Oláh Viktor János, Lukacsovich David, Winterer Jochen, Arszovszki Antónia, Lőrincz Andrea, Nusser Zoltan, Földy Csaba, Szabadics János

Abstract excerpt

CCK-expressing interneurons (CCK+INs) are crucial for controlling hippocampal activity. We found two firing phenotypes of CCK+INs in rat hippocampal CA3 area; either possessing a previously undetected membrane potential-dependent firing or regular firing phenotype, due to different low-voltage-activated potassium currents. These different excitability properties destine the two types for distinct functions,...

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Identifiers

PMID: 32490811
DOI: 10.7554/eLife.58515
PMCID: PMC7269670

Genes

CCK
CA3

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