Article
Mosaic Neurofibromatosis Type 1 With Multiple Cutaneous Diffuse and Plexiform Neurofibromas of the Lower Leg.
Anticancer research - 1 Jun 2020
Friedrich Reinhard E, Hagel Christian, Kohlrusch Felix K, Schanze Ina, Wieland Ilse, Zenker Martin
Abstract excerpt
BACKGROUND: Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease with complete penetrance and a very variable phenotype. Recent research has shown that postzygotic NF1 gene mutations occur to a far greater extent than previously thought. The phenotype of affected individuals reflects the time of somatic mutation and the phenotype is correspondingly diverse. This report describes histological...
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