Article
Molecular and pathological basis of HPV-negative cervical adenocarcinoma seen in a global study.
International journal of cancer - 1 Nov 2020
Jenkins David, Molijn Anco, Kazem Siamaque, Pirog Edyta C, Alemany Laia, de Sanjosé Silvia, Dinjens Winand, Quint Wim
Abstract excerpt
International surveys find HPV-negativity in up to 30% of cervical adenocarcinomas. We investigated the pathological diagnosis by expert consensus with immunohistochemistry and the presence of somatic mutations in recognised tumour genes in HPV-positive and negative cervical adenocarcinomas (CADC). A sample was selected of 45 paraffin-embedded cervical blocks diagnosed locally as usual cervical adenocarcinoma...
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