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ARTP mutation and adaptive laboratory evolution improve probiotic performance of Bacillus coagulans.

Applied microbiology and biotechnology - 1 Jul 2020

Liu KaiYue, Fang Hua, Cui FengJie, Nyabako Belinda Amanda, Tao TingLei, Zan XinYi, Chen Huayou, Sun WenJing

Abstract excerpt

Bacillus coagulans is a thermophilic, facultative anaerobic, spore-forming Gram-positive bacterium, which is used as a probiotic in animal feed and human dietary supplements. In the present study, a bile-resistant thermophilic B. coagulans WT-03 strain was isolated and genetically identified. Atmospheric pressure room temperature plasma (ARTP)-induced mutation combined with adaptive laboratory evolution (ALE) was...

Topics

Bacillus coagulans
Bile Acids and Salts
Biofilms
Cell Membrane
Cell Membrane Permeability
Directed Molecular Evolution
Fatty Acids
Hydrophobic and Hydrophilic Interactions
Mutagenesis
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasma Gases

Probiotics

Temperature

Source

Identifiers

PMID: 32474797
DOI: 10.1007/s00253-020-10703-y

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