Article
Ocular Manifestations of Chordin-like 1 Knockout Mice.
Cornea - 1 Sept 2020
Chen Di, Liu Yang, Shu Guanhua, Chen Chinfei, Sullivan David A, Kam Wendy R, Hann Steven, Fowler Megan, Warman Matthew L
Abstract excerpt
PURPOSE: In humans, loss-of-function mutations in the gene encoding Chordin-like 1 (CHRDL1) cause X-linked megalocornea (MGC1), characterized by bilateral corneal enlargement, decreased corneal thickness, and increased anterior chamber depth (ACD). We sought to determine whether Chrdl1 knockout (KO) mice would recapitulate the ocular findings found in patients with MGC1. METHODS: We generated mice with a Chrdl1...
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