Lipid Metabolism and Axon Degeneration: An ACOX1 Balancing Act.

Abstract excerpt

The loss of peroxisomal function has been implicated in many neurodegenerative diseases, yet the underlying molecular mechanisms are poorly understood. In this issue of Neuron, Chung et al. (2020) demonstrate that gain- and loss-of-function mutations in the peroxisomal acyl-CoA oxidase 1 (ACOX1) gene cause neurodegeneration via distinct molecular pathways in glia.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axons
• Share to Gain of Function Mutation
• Share to Lipid Metabolism