Application of Next-Generation Sequencing in Neurodegenerative Diseases: Opportunities and Challenges.

doi:10.1007/s12017-020-08601-7

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Application of Next-Generation Sequencing in Neurodegenerative Diseases: Opportunities and Challenges.

Neuromolecular medicine - 1 Jun 2021

Shademan Behrouz, Biray Avci Cigir, Nikanfar Masoud, Nourazarian Alireza

Abstract excerpt

Genetic factors (gene mutations) lead to various rare and prevalent neurological diseases. Identification of underlying mutations in neurodegenerative diseases is of paramount importance due to the heterogeneous nature of the genome and different clinical manifestations. An early and accurate molecular diagnosis are cardinal for neurodegenerative patients to undergo proper therapeutic regimens. The...

Topics

Alzheimer Disease
Base Sequence
Early Diagnosis
Epilepsy
Forecasting
Gene Library
Genetic Heterogeneity
Genetic Predisposition to Disease
Genetic Testing
High-Throughput Nucleotide Sequencing
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Diagnostic Techniques

Multiple Sclerosis

Neurodegenerative Diseases

Parkinson Disease

Exome Sequencing

Whole Genome Sequencing

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Open in PubMed

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PMID: 32399804
DOI: 10.1007/s12017-020-08601-7

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